Prymatologist Davis Okoye (Dwayne Johnson), who keeps people at a distance, has established a strong relationship with George - an extremely intelligent gorilla silver-breasted, whom he has been looking after since his birth. Unfortunately, due to a failed genetic experiment, this mild-mannered monkey turns into a gigantic, enraged beast. To make matters worse, it soon turns out that there are other animals that have undergone similar changes. Newly created alpha predators wade through North America, destroying everything in their path. Okoye joins forces with an environmentally rejected genetic engineer to find an antidote. At the same time, he tries to survive on an ever-changing battlefield and not only prevent a global catastrophe, but also save a terrifying being who once was his friend.